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What is Oxbryta and Why is it Dangerous?
Oxbryta (voxelotor) is a prescription medication developed by Global Blood Therapeutics (GBT) and approved by the FDA in 2019 to treat sickle cell disease (SCD). While it helps reduce sickling of red blood cells, serious liver damage and other side effects have been reported.
Key Facts About Oxbryta:
- Marketed as a breakthrough treatment for sickle cell disease.
- Works by increasing hemoglobin’s oxygen affinity.
- Linked to hepatotoxicity (liver injury) in clinical trials and post-market reports.
Does Oxbryta Cause Liver Damage?
Multiple studies and FDA reports suggest Oxbryta may cause severe liver injury, including:
- Elevated liver enzymes (ALT/AST)
- Drug-induced hepatitis
- Liver failure (rare cases)
Key Evidence:
- FDA Adverse Event Reports (FAERS): Over 100 cases of liver damage linked to Oxbryta.
- Clinical Trials: 10% of patients showed abnormal liver function tests.
- Black Box Warning (2023): FDA required updated labeling due to liver risks.
FDA Warnings & Side Effects of Oxbryta
The FDA has issued multiple warnings about Oxbryta’s risks:
Reported Side Effects:
Side Effect | Frequency |
Liver damage | 5-10% of patients |
Headaches | 20-30% |
Nausea & vomiting | 15-25% |
Fatigue | 10-20% |
FDA Actions:
- 2021: Added monitoring requirements for liver enzymes.
- 2023: Strengthened Black Box Warning—the FDA’s strictest safety alert.
Oxbryta Lawsuits and Settlements
Patients are filing lawsuits alleging:
- Failure to warn about liver damage risks.
- Misleading marketing by GBT (now Pfizer).
- Negligence in safety monitoring.
Potential Settlement Estimates:
Case Type | Expected Compensation |
Liver injury (mild) | $100,000 – $500,000 |
Liver failure (severe) | $1M – $5M+ |
Wrongful death | $2M – $10M+ |
Note: No global settlement yet, but cases are being filed.
Who Can File an Oxbryta Lawsuit?
You may qualify if:
✔ Took Oxbryta for at least 3 months
✔ Diagnosed with liver damage, hepatitis, or liver failure
✔ Experienced hospitalization or ongoing treatment
Even if you still take Oxbryta, you may have a claim.
Current Status of Oxbryta Lawsuits
- Growing litigation: Dozens of cases filed in federal courts.
- Potential MDL (Multi-District Litigation): Likely if more cases emerge.
- Pfizer’s liability: Acquired GBT in 2022, now responsible for lawsuits.
How to File an Oxbryta Lawsuit
- Consult a lawyer (free case review).
- Gather medical records (liver tests, prescriptions).
- File before your state’s deadline.
We work on contingency—no fees unless you win.
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Frequently Asked Questions
Yes, typically 1-3 years from diagnosis (varies by state).
Yes, if you have liver damage.
You may file a wrongful death lawsuit.
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